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BIOINFORMATICS 101: THE BASICS
Introduction
what is distance tree matrics
Distance-matrix methods of phylogenetic analysis explicitly rely on a measure of "genetic distance" between the sequences being classified and therefore they require the Multiple Sequence Alignment as an input.
UPGMA
A METHOD FOR MAKING DISTANCE BASED TREE
Application
UPGMA is used for creation of phenetic trees. It often to used for more sophisticated algorithm
1.
The algorithm can be used in to propose one order in aligned
2.
UPGMA assume a constant rate of evolution and is not wellregraded method for inferring relationship
3.
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