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BIOINFORMATICS 101: THE BASICS
Multiple Sequence Alignment
Structure Approach
Structural approach use structural information of one or more proteins that are being aligned.
Tools Used For
Structure Approach
Click on the tool name to visit the website!
Improve accuracy of multiple sequence alignment for closely related protein.
Accuracy
Able to distinguish reliable and non-reliable region of alignment by comparing 3D structures.
Distinguisable
Produce better alignment when the similarity of sequence is low.
Alignment
ADVANTAGES
ADVANTAGES
Can only align sequence when the structure of proteins are known.
Limited
Become less accurate when alignments are distantly related.
Inaccurate
Structure alignments take more time to be analysed than sequence alignments.
Slow
DISADVANTAGES
Steps on using
TCOFFEE
and
MUSCLE
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